Genetic epistasis between killer immunoglobulin-like receptors and human leukocyte antigens in Kawasaki disease susceptibility
نویسندگان
چکیده
منابع مشابه
Human diversity of killer cell immunoglobulin-like receptors and disease
Natural Killer (NK) cells are the third population of lymphocyte in the mononuclear cell compartment that triggers first-line of defense against viral infection and tumor transformation. Historically, NK cells were thought of as components of innate immunity based on their intrinsic ability to spontaneously kill target cells independent of HLA antigen restriction. However, it is now clear that ...
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Natural killer (NK) cells are a subset of lymphocytes which play a crucial role in early innate immune response against infection and tumor transformation. Furthermore, they secrete interferon-γ (IFN-γ) and tumor necrosis factor (TNF) prompting adaptive immu-nity. NK cells distinguish the unhealthy cells from the healthy ones through an array of cell-surface receptors. Human NK cells use inhibi...
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Genetic diversity of killer immunoglobulin-like receptors (KIRs) has been proposed to play an important role in immune responses of natural killer (NK) cells. Presently, the distributions and disease associations of KIRs have been interested in several research groups worldwide. Immunogenetic studies indicated that the difference of individual KIR associates with disease susceptibility or resis...
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During the Coronavirus disease 2019 (COVID-19) pandemic, children are less affected than adults, and underlying conditions and older age are associated with severe disease. Following the SARS-CoV-2 pandemic, outbreaks of cases with Kawasaki-like disease and a few others with the multisystem inflammatory syndrome in children related to COVID-19 (MIS-C) have been reported. Here, we report a two-y...
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Background: The innate immune system against malignancies is mainly orchestrated by natural killer cells, which carry out killing mechanisms by using their receptors, such as killer immunoglobulin-like receptors (KIRs). This study was designed to determine the diversity of KIR genes in non-melanoma skin cancers. Methods: A total of 160 subjects with skin cancer, including 60 cases of squamous c...
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ژورنال
عنوان ژورنال: Genes & Immunity
سال: 2015
ISSN: 1466-4879,1476-5470
DOI: 10.1038/gene.2015.34